The histopathologic evolution of recurrent herpes simplex labialis. – PubMed

On the whole, lysine prophylaxis had no effect on the recurrence rate of herpes simplex. Conversely, duration of the lesions and lesion pain decreased with increasing dosage (P = 0.05 and 0.03). Side effects from sunlamp exposure were minimal. Vacuolization was the earliest cytoplasmic alteration within keratinocytes. Group A comprised nine patients with a history of herpes labialis, group B 15 patients with a history of herpes keratitis. In vitro lymphoproliferative responses to herpes simplex virus antigen and natural killer cell activity were also significantly higher (P less than 0.05) in the TS group, whereas no significant difference in antibody titers to herpes simplex could be detected between the two groups.

Recurrent HSVL lesions occurred in 13 of 140 (9.3%) patients given epidural morphine but in only 6 of 583 (1.0%) not given epidural opioids (P less than 0.001). Conversely, duration of the lesions and lesion pain decreased with increasing dosage (P = 0.05 and 0.03). The experimental group received daily oral supplements of 1,000 mg 1-lysine. Correlation of the results with the occurrence of experimental lesions showed the inverse: the subgroup of H+S+ patients with UVR-induced lesions had lower titers of antibody and trends to higher levels of IFN-gamma and IL-2 than H+S+ patients who could not be induced (93 vs 149, P = 0.02; 501 vs 347 pg/ml, P = NS; 26 vs 11 pg/ml, P = NS, respectively). Conversely, duration of the lesions and lesion pain decreased with increasing dosage (P = 0.05 and 0.03). Undecylenic acid significantly reduced the incidence and duration of viral shedding and the duration and severity of itching but did not increase abortive episodes or reduce times to healing, crusting, or progression of lesion size.


Krueger, M.D. While lymphocytes of 10 control persons could be stimulated by HSV-AG, those of patients suffering from HSLR did not react to this antigen before onset of any therapy. Analyses according to institution and age, stage and size of lesion before therapy also indicated no benefit attributable to the drug. Postoperative herpes labialis was diagnosed by laboratory culture and microscopy. However, intraoral ulcerations may also be a sign of recurrent disease. Facial lesions of HSL may be unsightly, frequent outbreaks unpleasant, and the infection itself more severe locally and systemically in immunocompromised people.

Various methods of application (intravenous, oral, topical) are used, depending on whether the patient is experiencing recurrent HSL infection or erythema multiforme or is scheduled to undergo a dental procedure, a surgical procedure or a dermatological face peel (the latter being known triggers for recurrence). Drug treatment did not affect the development of lesions, measured by the frequency of macular and papular (aborted) lesions and mean maximum lesion size. Classical lesions are preceded by a prodrome, but others appear without warning, which makes them more difficult to treat. During convalescence, pronounced production of these mediators in response to antigenic stimulation with inactivated virus antigen preparations was regularly detected. Fees may apply. Interferon (IFN)-alpha and IFN-lambda are essential for antiviral immunity, but the precise role of IFN-lambda in vivo is not yet well understood.

In this placebo-controlled, randomized, double-blind clinical trial, a total of 105 patients with frequent episodes of recurrent herpes were randomized to either PD or placebo. The amount of vesicle fluid IFN was correlated with lesion age (r = 0.32, P = 0.024) and vesicle fluid virus titer (r = 0.59, P = 0.00004), but not with the clinical severity of the disease. Hormonal cause can also be the factor. Of the 254 subjects, 120 did not experience a recurrence and were not treated. The ether also failed to reduce appreciably lesion virus titer, even when lesions were cultured immediately after topical application. Lesion pain, area, and virus titer were determined for each group at the time of the first clinic visit and again on the following day, and the change in lesion severity between visits was examined.

We have evaluated the prophylactic effect of L-lysine monohydrochloride 1000 mg daily on recurrent herpes simplex labialis in 65 patients in a double-blind, placebo-controlled, crossover study. After axonal transmission from HSV-1-infected DRG neurons, both the number and size of viral cytopathic plaques in ECs was significantly reduced by addition of recombinant IFN-γ and IFN-α to ECs in the outer chamber in a concentration-dependent fashion.