COREY LAB — Lab Projects

The Corey Lab investigates the underlying mechanisms between herpes simplex virus pathogenesis and the host immune response; specifically, the associations between HSV-2 disease severity and the quantity, quality and diversity of tissue resident memory CD4+ and CD8+ T cells that persist after HSV-2 reactivation in humans. The SDE is modeled as an ODE with Ito noise unless stated otherwise. Marek’s disease virus (MDV), a poultry pathogen, has been increasing in virulence since the mid twentieth century. Interventional studies incorporating mathematical modeling of changes in HIV-1 RNA level during therapy with antiretroviral drugs have provided insights into HIV-1 pathogenesis [1, 2]; estimation of parameters that characterize rates of viral production and clearance, infected cell life spans, and phases of the viral replication cycle [3–5]; and means of determining the relative efficacies of single-agent and combination antiviral therapy [6, 7]. Currently, little is known about the viral kinetics of influenza A during infection within an individual. Marek’s disease virus (MDV), a poultry pathogen, has been increasing in virulence since the mid twentieth century.

Dr. To the Editor—We read with interest the article by Abbas et al, in which they model the potential impact of preexposure prophylaxis (PrEP) on human immunodeficiency virus (HIV) transmission and drug resistance in South Africa [1]. Theiler murine encephalomyelitis virus (TMEV) infection of a mouse’s central nervous system is biphasic: first the virus infects motor neurons (acute phase), and this is followed by a chronic phase in which the virus infects glial cells (primarily microglia and macrophages [Mϕ]) of the spinal cord white matter, leading to inflammation and demyelination. Presented in part: Department of Mathematical Modeling of Infectious Diseases, National Institute for Public Health and the Environment Meeting on Modeling the Transmission Dynamics of HIV and Other STIs, Bilthoven, The Netherlands, 8 March 2016. Methods. Abstract: Acute infection with human herpesvirus-6 induces physiological cell proliferation in persons without major immune deficiency.

N2 – Background: The continuation of developing Herpes simplex virus type-2 (HSV-2) prophylactic vaccines requires parallel mathematical modeling to quantify the effect on the population of these vaccines. Prevention of mother-to-child HIV transmission (PMTCT) strategies include combined short-course antiretrovirals during pregnancy (Option A), triple-drug antiretroviral treament (ART) during pregnancy and breastfeeding (Option B), or lifelong ART (Option B+). THURSDAY, Nov. abstract Herpes simplex virus-2 (HSV-2) shedding episodes in humans vary markedly in duration and virologic titer within an infected person over time, an observation that is unexplained. Conceived and designed the experiments: QW RQ JMH JW MS. Herpes simplex virus-2 (HSV-2) is a chronic reactivating infection that leads to recurrent shedding episodes in the genital tract.

Herpes simplex virus (HSV)-2 is periodically shed in the human genital tract, most often asymptomatically, and most sexual transmissions occur during asymptomatic shedding. Herpes simplex virus-2 (HSV-2) shedding episodes in humans vary markedly in duration and virologic titer within an infected person over time, an observation that is unexplained. Schiffer JT (2014) Herpes Simplex Virus-2 Genital Tract Shedding Is Not Predictable over Months or Years in Infected Persons. According to Umbach, scientists had long noted that during latency, herpes simplex 1 produces only one tiny product, dubbed latency associated transcript RNA (LAT RNA). Presented in part: International Herpesvirus Workshop, Seattle, WA, July 2006 (abstract 2.44); Annual Meeting of the Infectious Diseases Society of America, Toronto, Canada, October 2006 (abstract 699); Biennial Meeting of the International Society of Sexually Transmitted Diseases Research, Seattle, WA, July 2007 (abstract O-030). Utilization of new technological advances in molecular biology have enabled investigators to accurately measure the quantitative amount of viral nucleic acids produced within a host over time, thereby enabling investigations into host-viral interactions.

Johnston C, Zhu J, Jing L, Laing KJ, McClurkan CM, Klock A, Diem K, Jin L, Stanaway J, Tronstein E, Kwok WW, Huang ML, Selke S, Fong Y, Magaret A, Koelle DM, Wald A, Corey L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. HIV-1 and HSV-2 are frequent genital co-infections in women. AM received consulting fees from Immune Design and AiCuris. Human herpesvirus (HHV) –6A and HHV-6B are unique among herpesviruses in their ability to integrate into the telomeres of human chromosomes and be inherited in a Mendelian fashion.