Early human trials for DNA vaccines against viruses such as HIV demonstrated that the technique is well tolerated and safe, but unfortunately the expected levels of immune response weren’t reached. Furthermore, to ensure safety, regulatory agencies recommend elimination of antibiotic resistance markers from therapeutic and vaccine plasmid DNA vectors. Correctly synthesized and folded viral structural proteins present conformational epitopes that induce virus-specific neutralizing antibodies. In contrast, in Abo/o mice, none of the vaccines provided significant protection against the same lethal challenge dose of HSV-1. Coridon’s Herpes vaccine, which was recently announced to be 100% effective in protecting animals against Herpes Simplex Virus 2 infection, incorporates the NTC8485 antibiotic-free expression vector. Coridon was established to commercialise new vaccine technologies developed by Prof Ian Frazer, the developer of the Gardasil cervical cancer vaccine, and his team at the University of Queensland.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Publicly listed Allied Healthcare Group Limited (ASX:AHZ) is a major investor in Coridon. HPV is associated with several human cancers, most notably cervical cancer. Expression of mucins and MUC5AC, a major member of the mucin gene family in airway goblet cells, was assessed under hCLCA1 DNA vaccine challenges by periodic acid-Schiff staining, quantitative real-time PCR and Western blot, respectively, and the expression profile of granulocyte-macrophage colony-stimulating factor (GM-CSF), a critical cytokine in airway inflammation, was also examined by real-time PCR and immunocytochemistry. Not only was this an important milestone for Coridon and VGXI, this was one of our most viewed articles, ever! You may also find it helpful to participate in a herpes support group.
”I thought it was a cut,” he said. “Once we complete our analysis the team will be looking to take this program into a second clinical study in patients infected with the Herpes virus”. The HPV vaccine is administered in three doses over the course of six months. In the preclinical trial, 3 groups of 10 mice were given intradermal vaccinations. The company has laboratories within the Translational Research Institute at the Princess Alexandra Hospital in Brisbane, working in collaboration with the University of Queensland’s Diamantina Institute. ..To evaluate the efficacy of a 1-day course of valacyclovir in reducing the duration and severity of genital herpes recurrences and to measure the frequency of viral shedding episodes subsequent to antiviral therapy…
This study is ongoing, but not recruiting participants. The optimized vaccines, subcloned into a vector suitable for use in humans, also provided a high level of protection against the establishment of ganglionic latency, an important correlate of HSV reactivation and candidate endpoint for vaccines to proceed to clinical trials. The optimized vaccines, subcloned into a vector suitable for use in humans, also provided a high level of protection against the establishment of ganglionic latency, an important correlate of HSV reactivation and candidate endpoint for vaccines to proceed to clinical trials. JLD is also an inventor on patent US 2011/0287039 A1 and WO 2009/049351 A1. We ship all USA orders via USPS first class mail with delivery confirmation. Oral herpes is a common infection of the mouth area.
VGXI entered into a manufacturing agreement with Coridon Pty Ltd earlier this year to manufacture Coridon’s Herpes Simplex Virus 2 DNA vaccine for their upcoming Phase I clinical trial. “This is great progress for patients in not having to have additional surgeries and it represents huge potential for the future treatment of congenital heart disease and other cardiac defects” said chief executive officer Lee Rodne. IAN Frazer’s genital herpes vaccine has passed its first big test in human trials, with researchers showing the product is safe and appears to produce an immune response. If, as you suggest, worthind had ‘added in the detail that the dose was 50-500 times higher than would normally kill half the mice in the study.’, then it would have been perfectly correct and I would have said nothing about it. Coridon’s Herpes therapeutic vaccine seeks to stimulate the body’s immune system to produce T-cells a type of antibody – targeting the virus. Admedus’ Phase 1 trial has proved that its therapeutic vaccine for Herpes Simplex Virus (HSV-2) is safe in study subjects.